Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary

Steroid Production and Follicular Development of Neonatal Mouse Ovary during In Vitro Culture

steroid production and follicular development of neonatal mouse ovary during in vitro culture

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Effect of lysophosphatidic acid on the follicular development and the ‎expression of lysophosphatidic acid receptor genes during in vitro culture of ‎mouse ovary

Lysophosphatidic acid (LPA) known as a serum-derived growth factor, is involved in several cell physiological functions in the female reproductive system including: oocyte maturation, in vitro fertilization and embryo implantation by its transmembrane G protein-coupled receptors. The aim of the present study was to examine the effect of LPA on in vitro follicular development o...

Steroid Production and Follicular Development of Neonatal Mouse Ovary during in vitro Culture

BACKGROUND The aim of this study was to investigate follicular growth and steroid production in neonatal mouse ovary during in vitro culture. MATERIALS AND METHODS In this experimental study, 7-day-old mouse whole ovaries were cultured in α-MEM (medium supplemented with 100 mIU/ml recombinant follicle stimulating hormone, 1% insulin, transferrin and selenium (ITS), 5% fetal bovine serum (FBS)...

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA protein FANCD2. Here, we investigate whether HR-compromised cells are sensitive to acetaldehyde, similarly ...